Endocrine Abstracts

Ulceration is a common and severe complication of diabetes affecting 15% of the 200 million patients with diabetes worldwide. A significant proportion of these chronic wounds fail to respond to conventional treatment, hence major amputation is a feared outcome of diabetes. More than 60% of non-traumatic amputations in the western world are performed in the diabetic population. There exists a growing need for effective therapeutic agents to improve healing in these wounds.<...

Background: Diagnosis of small pancreatic neuroendocrine incidentalomas (PNETs-I) is increasing during last years and often their management remains unclear.Objective: To describe our experience with patients with PNETs-I in our institution.Methods: Since March 2000, patients with non functioning PNETs-I ≤30 mm were evaluated in our center, prospectively. A descriptive analysis of all patients and a comparative study between ...

Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) have important metabolic roles in the human body. IGFBP-3 (40 and 45 kD glycoforms) is the most abundant in serum, whereas IGFBP-2 (34 kD) and IGFBP-1 (29 kD) are present at lower concentrations.Most inflammatory diseases of the gastrointestinal tract are characterised by a cytokine- mediated inflammatory reaction, malnutrition and catabolism. The aim of this work was to detect possib...

Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) have important metabolic roles in the human body. IGFBP-3 (40 and 45 kD glycoforms) is the most abundant in serum, whereas IGFBP-2 (34 kD) and IGFBP-1 (29 kD) are present at lower concentrations.Most inflammatory diseases of the gastrointestinal tract are characterised by a cytokine- mediated inflammatory reaction, malnutrition and catabolism. The aim of this work was to detect possib...

While previous studies have shown relatively low concentrations of insulin-like growth factors (IGF)in human ejaculates, high levels of IGF binding protein-2 (IGFBP-2)have been reported. The IGF/IGFBP system was investigated in ejaculates from thirty men aged 23-46 years consulting a fertility clinic. Volume, viscosity, total and motile sperm counts were estimated by standard methods and each subject consented for the specimen to be used in this study. Local Ethical Committee ...

Gross cystic disease of the breast is a condition afflicting 7% of western women and confers an increased risk of developing breast cancer. Biochemical analyses of breast cyst fluid (BCF) have allowed the identification of various components of BCF and the classification of breast cysts into type I and II cysts. Gross cystic disease fluid proteins (GCDFP) are a family of proteins found in BCF and include albumin, apolipoprotein D and prolactin inducible protein (PIP). It is pr...

Background: Polymorphisms in angiotensin-converting enzyme (ACE) gene and angiotensin II type 1 receptor (AGTR1) gene have been assessed in previously multiple studies for association with diabetic nephropathy (DN), but results are still controversial.Aim: The aim of our study was to find out the role of ACE (I/D) and AGTR1 (A1166C) in genetic susceptibility of diabetic nephropathy in Belarusian population.Methods: The present case...

The Na+/I− symporter (NIS), a glycoprotein expressed at the basolateral plasma membrane of thyroid epithelial cells, mediates active I− uptake for the biosynthesis of thyroid hormones and radioiodide transport for diagnosis and treatment in thyroid cancer. Our cloning of the NIS cDNA and generation of anti-NIS antibodies provided the basis to investigate the decrease in I− transport in thyroid cancer relative to hea...

Background: One of the main effects of growth hormone therapy (rhGH) in the adult GH deficient patient (AGHD) is to positively modify body composition, with a reduction in fat mass (BF) and an increase in total lean mass (LM). However, the response to replacement therapy is highly variable and, contrary to what described in children, the potential predictive factors are not yet known.Aim of the study: To assess the impact of basal IGF-I levels on variati...

Introduction: National guidance recommends Level 3 carbohydrate counting (L3CC) is delivered within 2 weeks of diagnosis of Type I Diabetes Mellitus (T1DM) (NICE, 2015). This was introduced at Derbyshire Children’s Hospital in 2017. This service evaluation aimed to assess the impact of this on patients’ blood glucose, by recording HbA1c levels at quarterly intervals over 6 months. Methods: A comparison of quarterly HbA1c in children that receiv...